Monday, 27 December 2010

Hexomedine




Hexomedine may be available in the countries listed below.


Ingredient matches for Hexomedine



Hexamidine

Hexamidine diisetionate (a derivative of Hexamidine) is reported as an ingredient of Hexomedine in the following countries:


  • Belgium

  • Luxembourg

International Drug Name Search

Saturday, 25 December 2010

Halofuginone Hydrobromide




Halofuginone Hydrobromide may be available in the countries listed below.


Ingredient matches for Halofuginone Hydrobromide



Halofuginone

Halofuginone Hydrobromide (BANM, USAN) is also known as Halofuginone (Rec.INN)

International Drug Name Search

Glossary

BANMBritish Approved Name (Modified)
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Ceftazidima Normon




Ceftazidima Normon may be available in the countries listed below.


Ingredient matches for Ceftazidima Normon



Ceftazidime

Ceftazidime pentahydrate (a derivative of Ceftazidime) is reported as an ingredient of Ceftazidima Normon in the following countries:


  • Spain

International Drug Name Search

Wednesday, 22 December 2010

DepoCyt


Generic Name: cytarabine liposomal (sye TAR a been LYE poe SOE mal)

Brand Names: DepoCyt


What is DepoCyt (cytarabine liposomal)?

Cytarabine liposomal is a cancer medication. Cytarabine liposomal interferes with the growth of cancer cells and slows their growth and spread in the body.


Cytarabine liposomal is used to treat lymphoma associated with meningitis.


Cytarabine liposomal may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about DepoCyt (cytarabine liposomal)?


Do not use cytarabine liposomal if you are pregnant. It could harm the unborn baby. You should not receive this medication if you are allergic to cytarabine or if you have an active meningitis infection.

Before you receive cytarabine liposomal, tell your doctor about all of your medical conditions and any other medications you use. You may need a dose adjustment or special tests to safely use cytarabine liposomal.


Tell your caregivers at once if you have nausea and vomiting with headache and fever. These may be early signs of central nervous system damage. Call your doctor at once if you have a serious side effect such as neck stiffness or pain, extreme drowsiness, confusion, personality changes, seizure, loss of muscle control, problems with vision or hearing, severe numbness or tingling, or loss of bladder or bowel control.

What should I discuss with my healthcare provider before receiving DepoCyt (cytarabine liposomal)?


You should not receive this medication if you are allergic to cytarabine liposomal or if you have an active meningitis infection.

Before you receive cytarabine liposomal, tell your doctor about all of your medical conditions and any other medications you use. You may need a dose adjustment or special tests to safely use cytarabine liposomal:


FDA pregnancy category D. Do not use cytarabine liposomal if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether cytarabine liposomal passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving this medication.

How is cytarabine liposomal given?


Cytarabine liposomal is given as an injection through a needle placed into the space around your spinal cord. You will receive this injection in a clinic or hospital setting.


Tell your caregivers at once if you have nausea and vomiting with headache and fever. These may be early signs of central nervous system damage. To be sure cytarabine liposomal is not causing harmful effects, your doctor will need to check your progress on a regular basis. Do not miss any follow-up appointments.

What happens if I miss a dose?


Call your doctor for instructions if you miss an appointment for your cytarabine liposomal injection.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, headache and fever, confusion, and changes in personality or behavior.


What should I avoid while receiving DepoCyt (cytarabine liposomal)?


Follow your doctor's instructions about any restrictions on food, beverages, or activity.


DepoCyt (cytarabine liposomal) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • nausea and vomiting with headache and fever;




  • neck stiffness or pain, seizure (convulsions);




  • extreme drowsiness, loss of muscle control;




  • confusion, personality changes, problems with memory or concentration, sleep problems, agitation;




  • problems with speech, vision, hearing, or balance,




  • numbness, tingling, or burning pain that interferes with daily activities;




  • loss of bladder or bowel control;




  • pale skin, feeling light-headed or short of breath, rapid heart rate;




  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or




  • flu symptoms, sores in your mouth and throat.



Less serious side effects may include:



  • mild nausea or vomiting;




  • diarrhea, constipation, stomach pain;




  • swelling in your hands or feet;




  • dizziness, tired feeling;




  • joint pain, back pain; or




  • pain in your arms or legs.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect DepoCyt (cytarabine liposomal)?


There may be other drugs that can interact with cytarabine liposomal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More DepoCyt resources


  • DepoCyt Side Effects (in more detail)
  • DepoCyt Use in Pregnancy & Breastfeeding
  • DepoCyt Drug Interactions
  • DepoCyt Support Group
  • 0 Reviews for DepoCyt - Add your own review/rating


  • DepoCyt Prescribing Information (FDA)

  • DepoCyt MedFacts Consumer Leaflet (Wolters Kluwer)

  • DepoCyt Monograph (AHFS DI)

  • Cytarabine Liposomal Professional Patient Advice (Wolters Kluwer)

  • Depocyt Advanced Consumer (Micromedex) - Includes Dosage Information



Compare DepoCyt with other medications


  • Meningitis, Lymphomatous


Where can I get more information?


  • Your doctor or pharmacist can provide more information about cytarabine liposomal.

See also: DepoCyt side effects (in more detail)


Monday, 20 December 2010

Soclaf




Soclaf may be available in the countries listed below.


Ingredient matches for Soclaf



Cefotaxime

Cefotaxime sodium salt (a derivative of Cefotaxime) is reported as an ingredient of Soclaf in the following countries:


  • Indonesia

International Drug Name Search

Sunday, 19 December 2010

Alpha-Kiisin




Alpha-Kiisin may be available in the countries listed below.


Ingredient matches for Alpha-Kiisin



Chymotrypsin

Chymotrypsin is reported as an ingredient of Alpha-Kiisin in the following countries:


  • Vietnam

International Drug Name Search

Tuesday, 14 December 2010

Ester-Vit




Ester-Vit may be available in the countries listed below.


Ingredient matches for Ester-Vit



Ascorbic Acid

Ascorbic Acid calcium salt (a derivative of Ascorbic Acid) is reported as an ingredient of Ester-Vit in the following countries:


  • Turkey

International Drug Name Search

Sunday, 12 December 2010

Ciprofloxacine Almus




Ciprofloxacine Almus may be available in the countries listed below.


Ingredient matches for Ciprofloxacine Almus



Ciprofloxacin

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprofloxacine Almus in the following countries:


  • France

International Drug Name Search

Thursday, 9 December 2010

Cryptococcosis, Prophylaxis Medications


There are currently no drugs listed for "Cryptococcosis, Prophylaxis".

Learn more about Cryptococcosis, Prophylaxis





Drug List:

Friday, 3 December 2010

Zapain




Zapain may be available in the countries listed below.


UK matches:

  • Zapain Capsules and/or Co-Codamol 30/500 Capsules (SPC)

Ingredient matches for Zapain



Codeine

Codeine phosphate hemihydrate (a derivative of Codeine) is reported as an ingredient of Zapain in the following countries:


  • United Kingdom

Paracetamol

Paracetamol is reported as an ingredient of Zapain in the following countries:


  • United Kingdom

International Drug Name Search

Glossary

SPC Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Friday, 19 November 2010

Méladinine




Méladinine may be available in the countries listed below.


Ingredient matches for Méladinine



Methoxsalen

Methoxsalen is reported as an ingredient of Méladinine in the following countries:


  • France

  • Tunisia

International Drug Name Search

Thursday, 11 November 2010

Stazepine




Stazepine may be available in the countries listed below.


Ingredient matches for Stazepine



Carbamazepine

Carbamazepine is reported as an ingredient of Stazepine in the following countries:


  • Bulgaria

  • Hungary

  • Romania

International Drug Name Search

Monday, 8 November 2010

Buffered Aspirin


Generic Name: aspirin (oral) (AS pir in)

Brand Names: Arthritis Pain, Aspergum Cherry, Aspergum Orginal, Aspir 81, Aspir-Low, Aspirin Lite Coat, Aspirin Litecoat, Aspirin Low Dose, Aspirin Low Strength, Bayer Aspirin, Bayer Aspirin Regimen, Bayer Aspirin Sugar Free, Bayer Aspirin with Calcium, Bayer Childrens Aspirin, Bayer Low Strength, Bayer Plus, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Easprin, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Fasprin, Genacote, Halfprin, Litecoat Aspirin, Norwich Aspirin, St. Joseph Aspirin, St. Joseph Aspirin Adult Chewable, St. Joseph Aspirin Adult EC, Stanback Analgesic, Tri-Buffered Aspirin, YSP Aspirin, Zorprin


What is aspirin?

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.


Aspirin is used to treat mild to moderate pain, and also to reduce fever or inflammation. Aspirin is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.


Aspirin may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about aspirin?


There are many brands and forms of aspirin available and not all brands are listed on this leaflet.


Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Stop using this medication and call your doctor at once if you have any symptoms of bleeding in your stomach or intestines. Symptoms include black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.


Avoid drinking alcohol while you are taking aspirin. Alcohol may increase your risk of stomach bleeding.

Aspirin is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.


What should I discuss with my healthcare provider before taking aspirin?


Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children. Do not use this medication if you are allergic to aspirin, or if you have:

  • a recent history of stomach or intestinal bleeding;




  • a bleeding disorder such as hemophilia; or




  • an allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.



If you have any of these other conditions, you may need a dose adjustment or special tests to safely take aspirin:



  • asthma or seasonal allergies;




  • stomach ulcers;



  • liver disease;

  • kidney disease;


  • a bleeding or blood clotting disorder;




  • heart disease, high blood pressure, or congestive heart failure;




  • gout; or




  • nasal polyps.




If you are taking aspirin to prevent heart attack or stroke, avoid also taking ibuprofen (Advil, Motrin). Ibuprofen may make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form). This medication may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. Tell your doctor if you are pregnant or plan to become pregnant while you are taking aspirin. Aspirin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take aspirin?


Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger or smaller amounts, or use it for longer than recommended.


Take this medication with a full glass of water. Taking aspirin with food or milk can lessen stomach upset. Enteric-coated aspirin is specially formulated to be gentle on your stomach, but you may take it with food or milk if desired. Do not crush, chew, break, or open an enteric-coated or extended-release pill. Swallow the pill whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. The extended-release tablet is specially made to release medicine slowly in the body. Breaking this pill would cause too much of the drug to be released at one time.

The chewable tablet form of aspirin must be chewed before swallowing.


Keep the orally disintegrating tablet in its package until you are ready to take the medicine. Open the package and peel the back cover from the tablet. Using dry hands, place the tablet into your mouth. It will begin to dissolve right away, without water. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.


If you need to have any type of surgery, tell the surgeon ahead of time that you are taking aspirin. You may need to stop using the medicine for a short time.


Do not take this medication if you smell a strong vinegar odor in the aspirin bottle. The medicine may no longer be effective. Store aspirin at room temperature away from moisture and heat.

What happens if I miss a dose?


Since aspirin is often used as needed, you may not be on a dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include ringing in your ears, headache, nausea, vomiting, dizziness, confusion, hallucinations, rapid breathing, fever, seizure (convulsions), or coma.


What should I avoid while taking aspirin?


Do not use any other over-the-counter medication without first asking your doctor or pharmacist. Aspirin is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much aspirin. Read the label of any other medicine you are using to see if it contains aspirin.

Avoid taking an NSAID (non-steroidal anti-inflammatory drug) while you are taking aspirin. NSAIDs include ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.


Avoid drinking alcohol while you are taking aspirin. Alcohol may increase your risk of stomach bleeding. Avoid taking ibuprofen (Advil, Motrin) if you are taking aspirin to prevent stroke or heart attack. Ibuprofen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form).

Aspirin side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • black, bloody, or tarry stools;




  • coughing up blood or vomit that looks like coffee grounds;




  • severe nausea, vomiting, or stomach pain;




  • fever lasting longer than 3 days;




  • swelling, or pain lasting longer than 10 days; or




  • hearing problems, ringing in your ears.



Less serious side effects may include:



  • upset stomach, heartburn;




  • drowsiness; or




  • headache.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect aspirin?


Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with aspirin may cause you to bruise or bleed easily.


Before taking aspirin, tell your doctor if you are using any of the following drugs:



  • a blood thinner such as warfarin (Coumadin); or




  • another salicylate such as choline salicylate and/or magnesium salicylate (Magan, Doan's, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal), or salsalate (Disalcid).



This list is not complete and there may be other drugs that can interact with aspirin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More Buffered Aspirin resources


  • Buffered Aspirin Side Effects (in more detail)
  • Buffered Aspirin Use in Pregnancy & Breastfeeding
  • Buffered Aspirin Drug Interactions
  • Buffered Aspirin Support Group
  • 0 Reviews for Buffered Aspirin - Add your own review/rating


  • Aspirin Monograph (AHFS DI)

  • Aspirin Prescribing Information (FDA)

  • Aspirin MedFacts Consumer Leaflet (Wolters Kluwer)

  • Bayer Low Strength Delayed-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Ecotrin Advanced Consumer (Micromedex) - Includes Dosage Information

  • ZORprin Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Buffered Aspirin with other medications


  • Angina
  • Angina Pectoris Prophylaxis
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Aseptic Necrosis
  • Back Pain
  • Fever
  • Heart Attack
  • Ischemic Stroke
  • Ischemic Stroke, Prophylaxis
  • Juvenile Rheumatoid Arthritis
  • Kawasaki Disease
  • Myocardial Infarction, Prophylaxis
  • Niacin Flush
  • Osteoarthritis
  • Pain
  • Prosthetic Heart Valves
  • Prosthetic Heart Valves, Mechanical Valves
  • Revascularization Procedures, Prophylaxis
  • Rheumatic Fever
  • Rheumatoid Arthritis
  • Sciatica
  • Systemic Lupus Erythematosus
  • Thromboembolic Stroke Prophylaxis
  • Transient Ischemic Attack


Where can I get more information?


  • Your pharmacist can provide more information about aspirin.

See also: Buffered Aspirin side effects (in more detail)


Clindareach




Ingredient matches for Clindareach



Clindamycin

Clindamycin dihydrogen phosphate (a derivative of Clindamycin) is reported as an ingredient of Clindareach in the following countries:


  • United States

International Drug Name Search

Friday, 5 November 2010

Corsatrocin




Corsatrocin may be available in the countries listed below.


Ingredient matches for Corsatrocin



Erythromycin

Erythromycin ethylsuccinate (a derivative of Erythromycin) is reported as an ingredient of Corsatrocin in the following countries:


  • Indonesia

Erythromycin stearate (a derivative of Erythromycin) is reported as an ingredient of Corsatrocin in the following countries:


  • Indonesia

International Drug Name Search

Monday, 1 November 2010

Primidon Holsten




Primidon Holsten may be available in the countries listed below.


Ingredient matches for Primidon Holsten



Primidone

Primidone is reported as an ingredient of Primidon Holsten in the following countries:


  • Germany

  • Slovenia

International Drug Name Search

Monday, 25 October 2010

dipyridamole Oral, Intravenous


dye-pir-ID-a-mole


Commonly used brand name(s)

In the U.S.


  • Persantine

Available Dosage Forms:


  • Tablet

  • Capsule, Extended Release

  • Solution

  • Tablet, Extended Release

Therapeutic Class: Platelet Aggregation Inhibitor


Pharmacologic Class: Phosphodiesterase Inhibitor


Uses For dipyridamole


Dipyridamole is used to lessen the chance of stroke or other serious medical problems that may occur when a blood vessel is blocked by blood clots. It is given only when there is a larger-than-usual chance that these problems may occur. For example, it is given to people who have had diseased heart valves replaced by mechanical valves, because dangerous blood clots are especially likely to occur in these patients. Dipyridamole works by helping to prevent dangerous blood clots from forming.


Dipyridamole may also be used for other heart and blood conditions as determined by your doctor.


Dipyridamole is also sometimes used as part of a medical test that shows how well blood is flowing to your heart. For information on this use of dipyridamole, see Dipyridamole—Diagnostic (Systemic).


Dipyridamole is available only with your doctor's prescription.


Before Using dipyridamole


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dipyridamole, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to dipyridamole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


dipyridamole has been tested only in adults and in children older than 12 years of age. There is no specific information comparing use of dipyridamole in children younger than 12 years of age with use in other age groups.


Geriatric


Dipyridamole has not been studied specifically in older people taking the medicine regularly to prevent blood clots from forming. Although there is no specific information comparing this use of dipyridamole in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dipyridamole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using dipyridamole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acenocoumarol

  • Alteplase, Recombinant

  • Argatroban

  • Bivalirudin

  • Bromfenac

  • Celecoxib

  • Cilostazol

  • Citalopram

  • Dabigatran Etexilate

  • Dalteparin

  • Danaparoid

  • Desirudin

  • Desvenlafaxine

  • Diclofenac

  • Diflunisal

  • Drotrecogin Alfa

  • Duloxetine

  • Enoxaparin

  • Escitalopram

  • Etodolac

  • Fluoxetine

  • Flurbiprofen

  • Fluvoxamine

  • Fondaparinux

  • Heparin

  • Ibuprofen

  • Ibuprofen Lysine

  • Indomethacin

  • Ketoprofen

  • Ketorolac

  • Lepirudin

  • Magnesium Salicylate

  • Mefenamic Acid

  • Meloxicam

  • Milnacipran

  • Nabumetone

  • Naproxen

  • Nefazodone

  • Nepafenac

  • Oxaprozin

  • Paroxetine

  • Phenindione

  • Phenprocoumon

  • Piroxicam

  • Protein C, Human

  • Rivaroxaban

  • Salsalate

  • Sertraline

  • Streptokinase

  • Sulindac

  • Tinzaparin

  • Tolmetin

  • Venlafaxine

  • Warfarin

Using dipyridamole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Adenosine

  • Indomethacin

  • Tenecteplase

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of dipyridamole. Make sure you tell your doctor if you have any other medical problems, especially:


  • Chest pain—The chance of side effects may be increased

  • Low blood pressure—Large amounts of dipyridamole can make your condition worse

Proper Use of dipyridamole


dipyridamole works best when there is a constant amount in the blood. To help keep the amount constant, dipyridamole must be taken in regularly spaced doses, as ordered by your doctor.


dipyridamole works best when taken with a full glass (8 ounces) of water at least 1 hour before or 2 hours after meals. However, to lessen stomach upset, your doctor may want you to take the medicine with food or milk.


Dosing


The dose of dipyridamole will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dipyridamole. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For preventing blood clots:
    • For oral dosage form (tablets):
      • Adults—The usual dose is 75 to 100 milligrams (mg) four times a day taken together with an anticoagulant (blood-thinning) medicine.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of dipyridamole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using dipyridamole


Dipyridamole is sometimes used together with an anticoagulant (blood thinner) or aspirin. The combination of medicines may provide better protection against the formation of blood clots than any of the medicines used alone. However, the risk of bleeding may also be increased when dipyridamole is taken with aspirin. To reduce the risk of bleeding:


  • Do not take aspirin, or any combination medicine containing aspirin, unless the same doctor who directed you to take dipyridamole also directs you to take aspirin. This is especially important if you are taking an anticoagulant together with dipyridamole.

  • If you have been directed to take aspirin together with dipyridamole, take only the amount of aspirin ordered by your doctor . If you need a medicine to relieve pain or a fever, your doctor may not want you to take extra aspirin. It is a good idea to discuss this with your doctor, so that you will know ahead of time what medicine to take.

  • Your doctor should check your progress at regular visits.

Tell all medical doctors and dentists you go to that you are taking dipyridamole, and whether or not you are taking an anticoagulant (blood thinner) or aspirin together with it.


Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.


dipyridamole Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor as soon as possible if any of the following side effects occur:


Rare
  • Chest pain

  • gallstones

  • tightness or swelling of neck

  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Abdominal or stomach cramps

  • diarrhea

  • dizziness or lightheadedness

Less common
  • Flushing

  • headache

  • nausea or vomiting

  • weakness

Rare
  • General discomfort and/or unusual tiredness or weakness

  • hair loss

  • joint pain or swelling

  • muscle pain

  • runny nose

  • sneezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: dipyridamole Oral, Intravenous side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More dipyridamole Oral, Intravenous resources


  • Dipyridamole Oral, Intravenous Side Effects (in more detail)
  • Dipyridamole Oral, Intravenous Use in Pregnancy & Breastfeeding
  • Drug Images
  • Dipyridamole Oral, Intravenous Drug Interactions
  • Dipyridamole Oral, Intravenous Support Group
  • 0 Reviews for Dipyridamole Oral, Intravenous - Add your own review/rating


Compare dipyridamole Oral, Intravenous with other medications


  • Prosthetic Heart Valves
  • Radionuclide Myocardial Perfusion Study

Sunday, 24 October 2010

Buflomédil Biogaran




Buflomédil Biogaran may be available in the countries listed below.


Ingredient matches for Buflomédil Biogaran



Buflomedil

Buflomedil hydrochloride (a derivative of Buflomedil) is reported as an ingredient of Buflomédil Biogaran in the following countries:


  • France

International Drug Name Search

Thursday, 21 October 2010

N-Butil Bromuro de Hioscina




N-Butil Bromuro de Hioscina may be available in the countries listed below.


Ingredient matches for N-Butil Bromuro de Hioscina



Scopolamine

Scopolamine butylbromide (a derivative of Scopolamine) is reported as an ingredient of N-Butil Bromuro de Hioscina in the following countries:


  • Peru

  • Venezuela

International Drug Name Search

Tuesday, 19 October 2010

Sodide




Sodide may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Sodide



Sodium Iodide

Sodium Iodide is reported as an ingredient of Sodide in the following countries:


  • Australia

International Drug Name Search

Saturday, 16 October 2010

Chlorumagène




Chlorumagène may be available in the countries listed below.


Ingredient matches for Chlorumagène



Magnesium Hydroxide

Magnesium Hydroxide is reported as an ingredient of Chlorumagène in the following countries:


  • Monaco

International Drug Name Search

Thursday, 14 October 2010

Ambolyt




Ambolyt may be available in the countries listed below.


Ingredient matches for Ambolyt



Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Ambolyt in the following countries:


  • Bangladesh

International Drug Name Search

Friday, 17 September 2010

Phenoxybenzamine Livzon




Phenoxybenzamine Livzon may be available in the countries listed below.


Ingredient matches for Phenoxybenzamine Livzon



Phenoxybenzamine

Phenoxybenzamine hydrochloride (a derivative of Phenoxybenzamine) is reported as an ingredient of Phenoxybenzamine Livzon in the following countries:


  • China

International Drug Name Search

Tuesday, 7 September 2010

Oypalomin




Oypalomin may be available in the countries listed below.


Ingredient matches for Oypalomin



Iopamidol

Iopamidol is reported as an ingredient of Oypalomin in the following countries:


  • Japan

International Drug Name Search

Monday, 6 September 2010

Cliane




Cliane may be available in the countries listed below.


Ingredient matches for Cliane



Estradiol

Estradiol hemihydrate (a derivative of Estradiol) is reported as an ingredient of Cliane in the following countries:


  • Colombia

  • Peru

Norethisterone

Norethisterone 17ß-acetate (a derivative of Norethisterone) is reported as an ingredient of Cliane in the following countries:


  • Colombia

  • Peru

International Drug Name Search

Sunday, 22 August 2010

Marumunen




Marumunen may be available in the countries listed below.


Ingredient matches for Marumunen



Diltiazem

Diltiazem hydrochloride (a derivative of Diltiazem) is reported as an ingredient of Marumunen in the following countries:


  • Japan

International Drug Name Search

Friday, 13 August 2010

ISMN Jadran




ISMN Jadran may be available in the countries listed below.


Ingredient matches for ISMN Jadran



Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of ISMN Jadran in the following countries:


  • Croatia (Hrvatska)

International Drug Name Search

Monday, 9 August 2010

Lisinopril Rimafar




Lisinopril Rimafar may be available in the countries listed below.


Ingredient matches for Lisinopril Rimafar



Lisinopril

Lisinopril dihydrate (a derivative of Lisinopril) is reported as an ingredient of Lisinopril Rimafar in the following countries:


  • Spain

International Drug Name Search

Thursday, 5 August 2010

Kalimate




Kalimate may be available in the countries listed below.


Ingredient matches for Kalimate



Polystyrene Sulfonic Acid

Polystyrene Sulfonic Acid calcium salt (a derivative of Polystyrene Sulfonic Acid) is reported as an ingredient of Kalimate in the following countries:


  • Japan

  • Philippines

  • Taiwan

International Drug Name Search

Dimenidrinato




Dimenidrinato may be available in the countries listed below.


Ingredient matches for Dimenidrinato



Dimenhydrinate

Dimenidrinato (DCIT) is known as Dimenhydrinate in the US.

International Drug Name Search

Glossary

DCITDenominazione Comune Italiana

Click for further information on drug naming conventions and International Nonproprietary Names.

Tuesday, 27 July 2010

Dolorex




In some countries, this medicine may only be approved for veterinary use.


In the US, Dolorex (acetaminophen/phenyltoloxamine/salicylamide systemic) is a member of the drug class analgesic combinations and is used to treat Pain.

US matches:

  • Dolorex

  • Dolorex Forte

Ingredient matches for Dolorex



Butorphanol

Butorphanol is reported as an ingredient of Dolorex in the following countries:


  • Poland

Butorphanol tartrate (a derivative of Butorphanol) is reported as an ingredient of Dolorex in the following countries:


  • Australia

  • Belgium

  • France

  • Germany

  • Italy

  • Luxembourg

  • Netherlands

  • New Zealand

  • Switzerland

  • United States

Diclofenac

Diclofenac potassium salt (a derivative of Diclofenac) is reported as an ingredient of Dolorex in the following countries:


  • Georgia

  • Turkey

Diethylamine Salicylate

Diethylamine Salicylate is reported as an ingredient of Dolorex in the following countries:


  • Austria

Ketorolac

Ketorolac is reported as an ingredient of Dolorex in the following countries:


  • Peru

International Drug Name Search

Monday, 26 July 2010

Family Vlooien- en Tekenband




Family Vlooien- en Tekenband may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Family Vlooien- en Tekenband



Dimpylate

Dimpylate is reported as an ingredient of Family Vlooien- en Tekenband in the following countries:


  • Netherlands

International Drug Name Search

Saturday, 24 July 2010

Ninur




Ninur may be available in the countries listed below.


Ingredient matches for Ninur



Nitrofurantoin

Nitrofurantoin is reported as an ingredient of Ninur in the following countries:


  • Croatia (Hrvatska)

International Drug Name Search

Friday, 9 July 2010

Rinoglin




Rinoglin may be available in the countries listed below.


Ingredient matches for Rinoglin



Budesonide

Budesonide is reported as an ingredient of Rinoglin in the following countries:


  • Germany

International Drug Name Search

Sunday, 4 July 2010

Paroxetina Jaba




Paroxetina Jaba may be available in the countries listed below.


Ingredient matches for Paroxetina Jaba



Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of Paroxetina Jaba in the following countries:


  • Portugal

International Drug Name Search

Sunday, 27 June 2010

Glociten




Glociten may be available in the countries listed below.


Ingredient matches for Glociten



Chondroitin Polysulfate

Chondroitin Polysulfate sodium salt (a derivative of Chondroitin Polysulfate) is reported as an ingredient of Glociten in the following countries:


  • Vietnam

Glucosamine

Glucosamine sulfate (a derivative of Glucosamine) is reported as an ingredient of Glociten in the following countries:


  • Vietnam

International Drug Name Search

Tuesday, 15 June 2010

Merimac




Merimac may be available in the countries listed below.


Ingredient matches for Merimac



Rifampicin

Rifampicin is reported as an ingredient of Merimac in the following countries:


  • Indonesia

International Drug Name Search

Friday, 21 May 2010

Dryphen


Pronunciation: ah-seet-ah-MIN-oh-fen/klor-fen-EER-a-meen/fen-ill-EF-rin
Generic Name: Acetaminophen/Chlorpheniramine/Phenylephrine
Brand Name: Examples include Pyrroxate and Dryphen


Dryphen is used for:

Relieving symptoms of colds, hay fever, and allergies such as headache, sinus pain, nasal and sinus congestion, sneezing, watery eyes, runny nose, fever, and itching of the nose or throat. It may also be used for other conditions as determined by your doctor.


Dryphen is an antihistamine, decongestant, and pain reliever combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion and pain associated with sinus pressure, and dries the nose and chest.


Do NOT use Dryphen if:


  • you are allergic to any ingredient in Dryphen

  • you are taking sodium oxybate (GHB) or a monoamine oxidase (MAO) inhibitor (eg, phenelzine)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Dryphen:


Some medical conditions may interact with Dryphen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have breathing problems (eg, emphysema, asthma), heart disease, diabetes, difficulty urinating, an enlarged prostate, glaucoma, high blood pressure, an overactive thyroid, liver or kidney problems, adrenal gland problems (eg, pheochromocytoma), sleep apnea, trouble sleeping, stomach problems, urinary blockage, or viral hepatitis

Some MEDICINES MAY INTERACT with Dryphen. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), droxidopa, isoniazid, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects may be increased

  • Blood thinners (eg, warfarin), bromocriptine, furazolidone, MAO inhibitors (eg, phenelzine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the actions and side effects may be increased

  • Certain high blood pressure medicines such as beta-blockers (eg, atenolol) and guanethidine because these medicines may be less effective

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dryphen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Dryphen:


Use Dryphen as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Dryphen may be taken with food if it upsets your stomach.

  • If you miss a dose of Dryphen and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dryphen.



Important safety information:


  • Dryphen may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dryphen. Using Dryphen alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Dryphen will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

  • Do not exceed the recommended dose of Dryphen. Doing so will not improve your condition faster and may increase your risk for side effects.

  • If your symptoms do not improve within a few days or if they become worse, check with your doctor.

  • Dryphen contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.

  • Do not take diet or appetite control medicines while you are taking Dryphen without checking with your doctor.

  • If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Dryphen or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Dryphen may increase your risk for liver damage.

  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Dryphen.

  • Caution is advised when using Dryphen in the ELDERLY because they may be more sensitive to its effects.

  • Use Dryphen with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: It is unknown if Dryphen can cause harm to the fetus. If you become pregnant while taking Dryphen, discuss with your doctor the benefits and risks of using Dryphen during pregnancy. Some of the ingredients in Dryphen are excreted in breast milk. If you are or will be breast-feeding while you are using Dryphen, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Dryphen:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine or pale stools; difficulty urinating; hallucinations; high blood pressure; rapid pulse; severe nervousness; stomach pain; tremors; unusual fatigue; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Dryphen side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast or irregular heartbeat; fever; hallucinations; nausea; seizures; sweating; tremors; trouble breathing; unusual drowsiness or dizziness; vomiting.


Proper storage of Dryphen:

Store Dryphen at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dryphen out of the reach of children and away from pets.


General information:


  • If you have any questions about Dryphen, please talk with your doctor, pharmacist, or other health care provider.

  • Dryphen is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dryphen. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dryphen resources


  • Dryphen Side Effects (in more detail)
  • Dryphen Use in Pregnancy & Breastfeeding
  • Dryphen Drug Interactions
  • Dryphen Support Group
  • 0 Reviews for Dryphen - Add your own review/rating


  • Dryphen Concise Consumer Information (Cerner Multum)



Compare Dryphen with other medications


  • Cold Symptoms
  • Sinus Symptoms

Wednesday, 19 May 2010

Cardiopril




Cardiopril may be available in the countries listed below.


Ingredient matches for Cardiopril



Ramipril

Ramipril is reported as an ingredient of Cardiopril in the following countries:


  • India

  • Myanmar

International Drug Name Search

Monday, 17 May 2010

Prednisolone Sandoz




Prednisolone Sandoz may be available in the countries listed below.


Ingredient matches for Prednisolone Sandoz



Prednisolone

Prednisolone 21-(sodium 3-sulfobenzoate) (a derivative of Prednisolone) is reported as an ingredient of Prednisolone Sandoz in the following countries:


  • France

International Drug Name Search

Friday, 7 May 2010

Ibuprofen and Pseudoephedrine Hydrochloride




Ingredient matches for Ibuprofen and Pseudoephedrine Hydrochloride



Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofen and Pseudoephedrine Hydrochloride in the following countries:


  • United States

Pseudoephedrine

Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Ibuprofen and Pseudoephedrine Hydrochloride in the following countries:


  • United States

International Drug Name Search

Monday, 3 May 2010

Bromhist-PDX Syrup



brompheniramine maleate, dextromethorphan hydrobromide, phenylephrine hydrochloride and guaifenesin

Dosage Form: syrup
Bromhist-PDX Syrup

Bromhist-PDX Syrup


NDC 60258-429-16


Rx Only


DESCRIPTION

Bromhist-PDX Syrup is an antihistaminic, antitussive, nasal decongestant, expectorant syrup for oral administration and contains the following amounts of active ingredients in each 5 mL of syrup:


Brompheniramine Maleate...............................................2 mg

Dextromethorphan HBr....................................................5 mg

Phenylephrine HCl..........................................................5 mg

Guaifenesin..................................................................50 mg


Inactive Ingredients:  Propylene Glycol, Glycerin, Sorbitol, Maltitol, Citric Acid, Sodium Citrate, Sodium Saccharin, FD and C Red #40, FD and C Blue #1, Grape Flavor, Purified Water


Brompheniramine Maleate is an antihistamine having the chemical name, 2-Pyridinepropanamine,γ-(4-bromo-phenyl)-N, N-dimethyl-,(±)-,(Z)-2-butenedioate (1:1).






Dextromethorphan hydrobromide is an antitussive having the chemical name, morphinan, 3-methoxy-17methyl-, (9α, 13α, 14α)-, hydrobromide, monohydrate.







Phenylephrine hydrochloride is a mydriatic and a decongestant and occurs as bitter crystals.  The chemical name is: (-)-m-Hydroxy-α-[methylamino)methyl]benzyl alcohol hydrochloride.






Guaifenesin is an expectorant having the chemical name, 1, 2-propanediol, 3-(2-mthoxyphenoxy)-,(±)-.







Bromhist-PDX Syrup - Clinical Pharmacology


Antihistaminic, antitussive, nasal decongestant, and expectorant actions.


Brompheniramine Maleate

Brompheniramine maileate is a histamine antagonist, specifically an H1-receptor-blocking agent belonging to the alkylamine class of antihistamines.  Antihistamines appear to compete with histamine for receptor sites on effector cells.  Brompheniramine also has anticholinergic (drying) and sedative effects.  Among the antihistaminic effects, it antagonizes the allergic response (vasodilation, increased vascular permeability, increased mucus secretion) of nasal tissue.


Brompheniramine is well absorbed from the gastrointestinal tract, with peak plasma concentration after single, oral dose of 4 mg reached in 5 hours; urinary excretion is the major route of elimination, mostly as products of biodegradation; the liver is assumed to be the main site of metabolic transformation.


Dextromethorphan Hydrobromide

Dextromethorphan hydrobromide is a nonnarcotic antitussive with effectiveness equal to codeine.  It acts in the medulla oblongata to elevate the cough treshold.  Dextromethorphan does not produce analgesia or induce tolerance, and has no potential for addiction.  The onset of antitussive action occurs in 15 to 30 minutes after administration and is of long duration.  At usual doses, it will not depress respiration nor inhibit ciliary activity.  Dextromethorphan is rapidly metabolized with trace amounts of the parent compound in blood and urine.  About one-half of the administered dose is excreted in the urine as conjugated metabolites.


Phenylephrine Hydrochloride

Phenylephrine hydrochloride is a sympathomimetic that acts predominantly on alpha receptors and has little action on beta receptors.  Phenylephrine causes constriction of blood vessels, which shrinks swollen mucous membranes, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal decongestant while causing minimal central nervous system stimulation.


Guaifenesin

Guaifenesin, by increasing respiratory tract fluid, reduces the viscosity of tenacious secretions and acts as an expectorant.  Guafenesin is excreted in the urine mainly as gluconates and sulfonates.

Indications and Usage for Bromhist-PDX Syrup


Bromhist-PDX Syrup is indicated for symptomatic relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.

Contraindications


Patients with hypersensitivity or idiosyncrasy to any of its ingredients.  Do not use in newborn infants, premature infants, in patients with severe hypertension, sever coronary artery disease, ischemic heart disease, or in those receiving monoamine oxidase (MAO) inhibitors.  Antihistamines are contraindicated in patients with narrow-angle glaucoma, urinary retention, peptic ulcer, and during an asthma attack.  Antihistamines should not be used to treat lower respiratory tract conditions including asthma.

Warnings


Patients with persistent cough such as occurs with smoking, asthma, emphysema, or where cough is accompanied by excessive secretions should not take this product.


A persistent cough may be a sign of a serious condition.  If the cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor.


Use caution when giving to children or patients with chronic pulmonary disease, shortness of breath, difficulty breathing, asthma, emphysema, high blood pressure, heart disease, diabetes, thyroid disease, or difficulty in urination due to enlargement of the prostate gland unless directed by a physician.


Antihistamine may impair mental and physical abilities required for the performance of potentially hazardous tasks, such as driving a car or operating machinery, and may impair mental alertness in children.  Antihistamines may cause hyperexcitability, especially in children.  At doses higher than the recommended dose, nervousness, dizziness or sleeplessness may occur.  Especially in infants and small children, antihistamines in overdosage may cause hallucinations, convulsions, and death.


Do not exceed the recommended dosage.  If nervousness, dizziness, or sleeplessness occurs, discontinue use and consult a doctor.


Administration of dextromethorphan may be accompanied by histamine release and should be used with caution in atopic children.


Hypertensive crises can occur with concurrent use of sympathomimetic amines and monoamine oxidase (MAO) inhibitors, indomethacin, or with beta-blockers and methyldopa.  If a hypertensive crisis occurs, these drugs should be discontinued immediately and therapy to lower blood pressure should be instituted immediately.  Fever should be managed by means of external cooling.

Precautions


General

Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause of cough is identified, that modification of cough does not increase the risk of clinical or physiologic complications, and that appropriate therapy for the primary disease is provided.  Because of its antihistamine component, Bromhist-PDX Syrup should be used with caution in patients with a history of bronchial asthma, narrow-angle glaucoma, gastrointestinal obstruction, or urinary bladder neck obstruction.


Because of its sympathomimetic component, Bromhist-PDX Syrup should be used with caution in patients with diabetes, hypertension, heart disease, or thyroid disease.

Information for Patients


Patients should be warned about engaging in activities requiring mental alertness, such as driving a car or operating dangerous machinery.  Patients should be cautioned to get up slowly from a lying or sitting position and to lie down if nausea occurs.

Drug Interactions


Prescribe with caution to patients taking any of the following:


Monoamine oxidase (MAO) inhibitors - Hyperpyrexia, hypotension, and death have been reported coincident with the co-administration of MAO inhibitors and products containing dextromethorphan.  In addition, MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines.  MAO inhibitors may enhance the effect of pseudoephedrine and may produce an additive elevation of blood pressure (see WARNINGS).


Sympathomimetics - Used concurrently, may increase the effects of guaifenesin, thereby increasing the potential for side effects.  Sympathomimetics may reduce the antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids.


Central nervous system (CNS) depressants - Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.).





Drug/Laboratory Test Interactions


Guaifenesin has been reported to interfere with clinical laboratory determinations of urinary 5-hydroxyindoleacetic acid (5-HIAA) and urinary vanillylmandelic acid (VMA).


Carcinogenesis, Mutagenesis, Impairment of Fertility


Animal studies to assess the long-term carcinogenic and mutagenic potential or the effect of fertility in animals or humans have not been performed.

Pregnancy, Teratogenic Effects-Pregnancy Category C


Animal reproduction studies have not been conducted with Bromhist-PDX Syrup.  It is also not known whether Bromhist-PDX Syrup can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.  Bromhist-PDX Syrup should be given to a pregnant woman only if clearly needed.


Reproduction studies of brompheniramine maleate in rats and mice at doses up to 16 times the maximum human dose have revealed no evidence of impaired fertility or harm to the fetus.

Nursing Mothers


Caution should be exercised when Bromhist-PDX is administered to a nursing woman due to the risk of intolerance of antihistamines in small infants generally, and in newborns and premature infants in particular.

Pediatric Use


No recommended for use in patients under 2 years of age.
The elderly (60 years of age or older) are more likely to exhibit adverse reactions.  Caution should be taken when prescribing this drug to the elderly.

Adverse Reactions


The most frequent adverse reactions to Bromhist-PDX Syrup include sedation; dryness of mouth, nose, and throat; thickening of bronchial secretins; dizziness.  Other adverse reactions may include:


Dermatologic - Urticaria, drug rash, photosensitivity, and pruritus.


Cardiovascular System - Hypotension, hypertension, cardiac arrhythmias, palpitations, tachycardia, pallor.


Central Nervous System (CNS) - Distrubed coordination, tremor, irritability, insomnia, visual disturbances, weakness, nervousness, convulsions, headache, euphoria, dysphoria, restlessness, insomnia, hallucinations, and CNS depression.


G.U. System - Urinary frequency, difficult urination.


G.I. System - Epigastric discomfort, anorexia, nausea, vomiting, diarrhea or constipation.


Respiratory System - Respiratory difficulty, tightness of chest and wheezing, shortness of breath.


Hematologic System - Hemolytic anemia, thrombocytopenia, agranulocytosis.

Overdosage


Signs and Symptoms

Overdosage of phenylephrine may be associated with CNS stimulation, tachycardia, hypertension, and cardiac arrhythmias.  Dextromethorphan in toxic doses will cause drowsiness, ataxia, nystagmus, opisthotonos and convulsive seizures.  Central nervous system effects from overdosage of bromphenirmine may vary from depression to stimulation, especially in children.  Anticholinergic effects may also occur.


Toxic Doses

The acute toxicity of guaifenesin is low and overdosage is unlikely to produce serious toxic effects.  In laboratory animals no toxicity resulted when guaifenesin was administered by stomach t.b. in doses up to 5 grams/kg.  Data suggest that individuals may respond in an unexpected manner to apparently small amounts of a particular drug.  A 2 1/2 year old child survived the ingestion of 21 mg/kg of dextromethorphan exhibiting only ataxia, drowsiness, and fever, but seizures have been reported in 2 children following the ingestion of 13-17 mg/kg.  One case of toxic psychosis (hyperactivity, marked visual and auditory hallucinations) after ingestion of a single 300 mg dose of dextromethorphan has been reported.  The toxic dose of phenylephrine should be less than that of ephedrine, which is estimated to be 50 mg/kg.  Another 2 1/2 year old child survived a dose of 300-900 mg of brompheniramine.


Treatment

Induce emesis if patient is alert and is seen prior to 6 hours following ingestion.  Precautions against aspiration must be taken, especially in infants and small children.  Gastric lavage may be carried out, although in some instances tracheotomy may be necessary prior to lavage.  Naloxone hydrochloride 0.005 mg/kg intravenously may be of value in reversing CNS depression that may occur from an overdose of dextromethorpan.  CNS stimulants may counter CNS depression.  Should CNS hyperactivity or convulsive seizures occur, intravenous short-acting barbiturates may be indicated.  Hypertensive responses and/or tachycardia should be treated appropriately.  Oxygen, intravenous fluids, and other supportive measures should be employed as indicated.

DOSAGE* AND ADMINISTRATION


Adults and children 12 years of age and over:

2 teaspoonfuls every 4 to 6 hours, not to exceed 12 teaspoonfuls in 24 hours.

Children 6 to under 12 years of age:

1 teaspoonful every 4 to 6 hours, not to exceed 6 teaspoonfuls in 24 hours.

Children 2 to under 6 years of age:

1/2 teaspoonful every 4 to 6 hours; not to exceed 3 teaspoonfuls in 24 hours.

Not recommended for use in children under 2 years of age.

*In mild cases or in particularly sensitive patients, less frequent or reduced doses may be appropriate and adequate.

How is Bromhist-PDX Syrup Supplied


Bromhist-PDX Syrup is an alcohol-free, purple syrup with a grape flavor in 16 fl oz (473 mL) bottles, NDC 60258-429-16.


WARNING:  KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.  IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.


Rx Only


Store at 20°-25°C(68°-77°F) [see USP Controlled Room Temperature].  Excursions permitted to 15°-30°C(59°-86°F).


Dispense in a tight, light-resistant container as defined in the USP/NF with a child resistant closure.


Tamper evident by foil seal under cap.  Do not use if foil seal is broken or missing.


Manufactured for:

Cypress Pharmaceuticals, Inc.

Madison, MS  39110


I236 Rev. 4/10


Product Packaging:


The packaging below represents label currently used:


Principal display panel and side panel for 473 mL label:


NDC 60258-429-16


Bromhist-PDX Syrup


Antihistamine/Antitussive/Nasal Decongestant/Expectorant


Each teaspoonful (5 mL) for oral adminstration contains:

Brompheniramine Maleate.......................................2 mg

Dextromethorphan HBr............................................5 mg

Phenylephrine HCl...................................................5 mg

Guaifenesin...........................................................50 mg


ALCOHOL FREE


Rx Only


Cypress Pharmaceutical, INC.


16 fl oz (473 mL)


DOSAGE* AND ADMINISTRATION:

Adults and children 12 years of age and over:  2 teaspoonfuls every 4 to 6 hours, not to exceed

12 teaspoonfuls in 24 hours.

Children 6 to under 12 years of age:  1 teaspoonful every 4 to 6 hours, not to exceed

6 teaspoonfuls in 24 hours.

Children 2 to under 6 years of age:  1/2 teaspoonful every 4 to 6 hours, not to exceed

3 teaspoonfuls in 24 hours.

Not recommended for use in children under 2 years of age.

*In mild cases or in particularly sensitive patients, less frequent or reduced doses

may be appropriate and adequate.


See attached insert for full prescribing information.


WARNING:  KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT

A POISON CONTROL CENTER IMMEDIATELY.


Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].

Excursions permitted to 15°-30°C (59°-86°F).


Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.


Tamper evident by foil seal under cap.  Do not use if foil seal is broken or missing.


This package not to be dispensed to the patient.


Call your doctor for medical advice about side effects.  You may report side effects to FDA at 1-800-FDA-1088.


Mfg. for:  Cypress Pharmaceutical, Inc., Madison, MS  39110

L462 Rev 4/10



























BROMHIST  PDX
brompheniramine maleate, dextromethorphan hydrobromide, phenylephrine hydrochloride, guaifenesin  syrup










Product Information
Product TypeHUMAN PRESCRIPTION DRUGNDC Product Code (Source)60258-429
Route of AdministrationORALDEA Schedule    

















Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Brompheniramine Maleate (Brompheniramine)Brompheniramine Maleate2 mg  in 5 mL
Dextromethorphan Hydrobromide (Dextromethorphan)Dextromethorphan Hydrobromide5 mg  in 5 mL
Phenylephrine Hydrochloride (Phenylephrine)Phenylephrine Hydrochloride5 mg  in 5 mL
Guaifenesin (Guaifenesin)Guaifenesin50 mg  in 5 mL





Inactive Ingredients
Ingredient NameStrength
No Inactive Ingredients Found


















Product Characteristics
Color    Score    
ShapeSize
FlavorGRAPEImprint Code
Contains      










Packaging
#NDCPackage DescriptionMultilevel Packaging
160258-429-16473 mL In 1 BOTTLENone










Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
unapproved drug other04/28/2006


Labeler - Cypress Pharmaceutical, Inc (790248942)
Revised: 06/2010Cypress Pharmaceutical, Inc

More Bromhist-PDX Syrup resources


  • Bromhist-PDX Syrup Side Effects (in more detail)
  • Bromhist-PDX Syrup Dosage
  • Bromhist-PDX Syrup Use in Pregnancy & Breastfeeding
  • Bromhist-PDX Syrup Drug Interactions
  • Bromhist-PDX Syrup Support Group
  • 0 Reviews for Bromhist-PDX - Add your own review/rating


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Repligen may be available in the countries listed below.


Ingredient matches for Repligen



Metronidazole

Metronidazole is reported as an ingredient of Repligen in the following countries:


  • Argentina

International Drug Name Search

Rifadin


Rifadin is a brand name of rifampin, approved by the FDA in the following formulation(s):


RIFADIN (rifampin - capsule; oral)



  • Manufacturer: SANOFI AVENTIS US

    Approved Prior to Jan 1, 1982

    Strength(s): 300MG [RLD][AB]

RIFADIN (rifampin - injectable; injection)



  • Manufacturer: SANOFI AVENTIS US

    Approval date: May 25, 1989

    Strength(s): 600MG/VIAL [RLD][AP]

Has a generic version of Rifadin been approved?


Yes. The following products are equivalent to Rifadin:


rifampin capsule; oral



  • Manufacturer: LANNETT

    Approval date: March 28, 2008

    Strength(s): 300MG [AB]


  • Manufacturer: SANDOZ

    Approval date: May 28, 1997

    Strength(s): 300MG [AB]


  • Manufacturer: VERSAPHARM

    Approval date: March 14, 2001

    Strength(s): 300MG [AB]

rifampin injectable; injection



  • Manufacturer: BEDFORD

    Approval date: October 29, 1999

    Strength(s): 600MG/VIAL [AP]


  • Manufacturer: PFIZER

    Approval date: May 22, 2008

    Strength(s): 600MG/VIAL [AP]


  • Manufacturer: VERSAPHARM INC

    Approval date: September 21, 2010

    Strength(s): 600MG/VIAL [AP]

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Rifadin. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.




Related Patents

There are no current U.S. patents associated with Rifadin.

See also...

  • Rifadin Consumer Information (Wolters Kluwer)
  • Rifadin Consumer Information (Cerner Multum)
  • Rifadin Advanced Consumer Information (Micromedex)
  • Rifampin Consumer Information (Wolters Kluwer)
  • Rifampin Capsules Consumer Information (Wolters Kluwer)
  • Rifampin Consumer Information (Cerner Multum)
  • Rifampin Intravenous Advanced Consumer Information (Micromedex)
  • Rifampin Oral, Intravenous Advanced Consumer Information (Micromedex)
  • Rifampin AHFS DI Monographs (ASHP)